Phytosphingosine (t-C18 Sphingoid Base)
Número CAS: 554-62-1
Phytosphingosine is a natural sphingoid base (t-C18) produced by yeast fermentation, functioning as a direct precursor to ceramide biosynthesis in the skin and a potent antimicrobial agent against acne-causing bacteria (Cutibacterium acnes) and Pityrosporum ovale. By stimulating ceramide synthesis it reinforces the lamellar lipid structure of the stratum corneum, restoring barrier function in compromised skin. Used at 0.05–0.1% in anti-acne, ceramide-booster, and sensitive skin formulations.
Especificaciones Técnicas
| purity | ≥95.0% (HPLC) |
| storage | Sealed, cool and dry; 15–25°C; stable 24 months |
| appearance | White crystalline powder |
| solubility | Soluble in ethanol; dispersible in water with cosolvents |
| heavy metals | <10 ppm |
| melting point | 95–100°C |
| recommended dosage | 0.05–0.1% |
Aplicaciones
- Anti-acne serums and spot treatments
- Ceramide-booster barrier repair moisturizers
- Sensitive and atopic skin barrier creams
- Scalp care for dandruff (anti-Pityrosporum activity)
- Post-procedure skin recovery formulations
Características Principales
- Phytosphingosine directly stimulates ceramide biosynthesis for clinical-grade barrier restoration
- Potent antimicrobial activity against C. acnes and P. ovale without antibiotic resistance risk
- Yeast fermentation origin provides a consistent, vegan-compatible supply with high batch reproducibility
- Effective at ultra-low concentrations (0.05–0.1%), minimizing cost-in-use while maximizing efficacy