Colloidal Silicon Dioxide (Aerosil 200)
CAS Number: 7631-86-9
Colloidal Silicon Dioxide (Aerosil 200) is a fumed amorphous silica with a surface area of approximately 200 m²/g, used as a glidant and adsorbent in pharmaceutical formulations. At low concentrations (0.1–0.5%), it significantly improves powder flow by reducing inter-particle friction. It is also used as a suspending agent and thickener in liquid and semisolid preparations.
Technical Specifications
| appearance | White, light, fluffy amorphous powder |
| SiO2 content (%) | ≥99.8 |
| loss on drying (%) | ≤2.5 |
| loss on ignition (%) | ≤1.0 |
| pH (4% aq. dispersion) | 3.7–4.7 |
| specific surface area (m²/g) | 175–225 |
Applications
- Tablet and capsule glidant
- Adsorbent for liquid APIs
- Suspending agent in oral liquids
- Thickener in topical preparations
- Desiccant in solid dosage forms
Key Features
- Effective glidant at 0.1–0.5% level
- High surface area for adsorption
- Amorphous, non-crystalline silica
- USP/NF, EP compliant
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CAS Number
7631-86-9
Category
Pharmaceutical ExcipientsAvailability
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