Copovidone VA64 (Kollidon VA64)
CAS Number: 25086-89-9
Copovidone VA64 is a copolymer of vinylpyrrolidone and vinyl acetate in a 6:4 ratio, known commercially as Kollidon VA64. It combines the excellent binding properties of PVP with the plasticizing effect of PVA, making it ideal for hot melt extrusion (HME) and spray-drying applications for amorphous solid dispersion formation. It is widely used to enhance bioavailability of BCS II and IV drugs.
Technical Specifications
| K-value | 25.2–30.8 |
| Tg (°C) | ~101 |
| appearance | White to slightly yellowish powder |
| pH (5% solution) | 3.0–5.0 |
| loss on drying (%) | ≤5.0 |
| nitrogen content (%) | 7.0–8.0 |
Applications
- Hot melt extrusion (HME) carrier
- Spray-dried amorphous solid dispersions
- Wet granulation binder
- Film coating polymer
- Solubility enhancement for BCS II/IV drugs
Key Features
- Ideal for hot melt extrusion processes
- Enhances bioavailability of poorly soluble drugs
- Lower Tg enables easier processing
- USP/NF, EP compliant
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CAS Number
25086-89-9
Category
Pharmaceutical ExcipientsAvailability
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