Hydroxypropyl Methylcellulose E5 (HPMC E5)
CAS Number: 9004-65-3
Hydroxypropyl Methylcellulose E5 (HPMC E5) is a low-viscosity grade of HPMC with a 2% aqueous solution viscosity of approximately 5 mPa·s, widely used as a film coating agent, binder, and viscosity modifier. Its excellent film-forming properties and solubility in both water and organic solvents make it suitable for immediate-release coating and tablet binding applications.
Technical Specifications
| appearance | White to slightly off-white powder |
| pH (2% solution) | 5.0–8.0 |
| heavy metals (ppm) | ≤20 |
| loss on drying (%) | ≤5.0 |
| methoxy content (%) | 28.0–30.0 |
| viscosity 2% aq. (mPa·s) | 4.0–6.0 |
Applications
- Immediate release film coating
- Tablet binder in wet granulation
- Ophthalmic solution viscosity modifier
- Sustained release matrix (higher viscosity grades)
- Controlled release coating
Key Features
- Low viscosity for film coating applications
- Soluble in water and organic solvents
- Excellent film formation and adhesion
- USP/NF, EP, JP compliant
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CAS Number
9004-65-3
Category
Pharmaceutical ExcipientsAvailability
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