Hydroxypropyl Methylcellulose K4M (HPMC K4M)
CAS Number: 9004-65-3
HPMC K4M is a high-viscosity, sustained-release grade of hydroxypropyl methylcellulose with a 2% aqueous viscosity of approximately 4000 mPa·s. It forms a robust gel barrier upon hydration, controlling drug diffusion and enabling extended drug release profiles. It is the cornerstone excipient in hydrophilic matrix tablet technology.
Technical Specifications
| appearance | White to slightly off-white powder |
| pH (2% solution) | 5.0–8.0 |
| loss on drying (%) | ≤5.0 |
| methoxy content (%) | 19.0–24.0 |
| viscosity 2% aq. (mPa·s) | 3000–5600 |
| hydroxypropoxy content (%) | 7.0–12.0 |
Applications
- Hydrophilic matrix sustained-release tablets
- Controlled drug release systems
- Bioadhesive formulations
- Ophthalmic gel preparations
- Modified-release capsule filling
Key Features
- Robust gel-forming for sustained release
- pH-independent drug release
- Versatile for matrix tablets and coatings
- USP/NF, EP, JP compliant
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CAS Number
9004-65-3
Category
Pharmaceutical ExcipientsAvailability
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