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Glyceryl Behenate (Compritol 888 ATO)

CAS Number: 18641-57-1

Glyceryl Behenate (Compritol 888 ATO) is a mixture of glycerol mono-, di-, and tribehenate used as a lipid matrix former for sustained-release tablets and pellets, and as a lubricant in solid dosage forms. Its high melting point (65–77°C) enables melt granulation and hot melt extrusion processes. It provides pH-independent controlled release by forming a lipid barrier around the drug.

Technical Specifications

appearanceWhite to off-white waxy powder or pellets
iodine value≤3.0
loss on drying (%)≤1.0
melting range (°C)65–77
acid value (mg KOH/g)≤4.0
hydroxyl value (mg KOH/g)40–65

Applications

  • Lipid matrix sustained-release tablets
  • Melt granulation binder
  • Hot melt extrusion lipid carrier
  • Tablet lubricant
  • Pellet coating for controlled release

Key Features

  • Lipid matrix for pH-independent SR
  • High melting point enables melt processing
  • Dual function as lubricant and SR matrix
  • Ph.Eur., NF compliant

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Glyceryl Behenate (Compritol 888 ATO) chemical structure

CAS Number

18641-57-1

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