Hypromellose Acetate Succinate (HPMCAS)
CAS Number: 71138-97-1
Hypromellose Acetate Succinate (HPMCAS) is a cellulose derivative used as an enteric coating polymer and as a carrier in amorphous solid dispersions (ASD) for bioavailability enhancement. It dissolves above pH 5.5 to 6.8 depending on the grade (LF, MF, HF), providing targeted intestinal drug release. It is the most widely used polymer for spray-dried dispersions of poorly soluble drugs.
Technical Specifications
| appearance | White to off-white powder |
| pH of dissolution | 5.5–6.8 (grade dependent) |
| acetyl content (%) | 5.0–14.0 |
| loss on drying (%) | ≤5.0 |
| succinoyl content (%) | 4.0–18.0 |
Applications
- Enteric film coating
- Spray-dried amorphous solid dispersions
- Hot melt extrusion carrier
- Bioavailability enhancement of BCS II drugs
- Delayed-release capsule coatings
Key Features
- Grade-specific pH-dependent dissolution
- Excellent ASD carrier for oral bioavailability
- Three grades: LF, MF, HF
- USP/NF, EP compliant
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CAS Number
71138-97-1
Category
Pharmaceutical ExcipientsAvailability
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