Croscarmellose Sodium (Ac-Di-Sol)
CAS Number: 74811-65-7
Croscarmellose Sodium is a crosslinked polymer of carboxymethylcellulose sodium used as a superdisintegrant in solid oral dosage forms. It provides rapid and efficient tablet disintegration through a combination of swelling and wicking mechanisms, and is effective at low concentrations (1–5%). Compliant with USP/NF, EP, and JP monographs.
Technical Specifications
| appearance | White or almost white hygroscopic powder |
| loss on drying (%) | ≤10.0 |
| pH (1% suspension) | 5.0–7.0 |
| sodium content (%) | 4.0–8.0 |
| degree of substitution | 0.60–0.85 |
Applications
- Superdisintegrant in tablets and capsules
- Immediate release formulations
- Orally disintegrating tablets (ODT)
- Wet and dry granulation disintegrant
- Direct compression disintegrant
Key Features
- High swelling capacity for rapid disintegration
- Effective at low concentrations (1–5%)
- Compatible with most APIs and excipients
- USP/NF, EP, JP compliant
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CAS Number
74811-65-7
Category
Pharmaceutical ExcipientsAvailability
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