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Methylparaben (Pharmaceutical Grade)

CAS Number: 99-76-3

Pharmaceutical grade Methylparaben (methyl 4-hydroxybenzoate) is a widely used antimicrobial preservative in oral, topical, and parenteral formulations. It exhibits broad-spectrum antimicrobial activity and is typically used in combination with propylparaben for synergistic effect. It is effective over a wide pH range (4–8) and is soluble in water and most organic solvents.

Technical Specifications

assay (%)99.0–101.0
appearanceWhite crystalline powder
sulfated ash (%)≤0.1
heavy metals (ppm)≤10
loss on drying (%)≤0.5
melting range (°C)125–128

Applications

  • Oral liquid and suspension preservative
  • Topical cream and lotion preservative
  • Parenteral formulation preservative
  • Combined with propylparaben for broad spectrum
  • Cosmetic and personal care preservative

Key Features

  • Broad-spectrum antimicrobial at low levels
  • Effective across wide pH range (4–8)
  • Synergistic with propylparaben
  • USP/NF, EP compliant

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Methylparaben (Pharmaceutical Grade) chemical structure

CAS Number

99-76-3

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