cosmetic active ingredients

Acetyl Hexapeptide-3 (Argireline)

CAS: 616204-22-9

Acetyl Hexapeptide-3 (Argireline) is a synthetic hexapeptide derived from the N-terminal sequence of SNAP-25, a protein involved in neurotransmitter release, that inhibits muscle contraction signals at the neuromuscular junction to reduce expression wrinkles similarly to botulinum toxin but without injections. It is the most studied topical 'botox alternative' peptide. Used at 3–10% in anti-wrinkle serums and eye treatments.

cosmetic active ingredients

Adenosine (Cosmetic Grade)

CAS: 58-61-7

Adenosine is a naturally occurring purine nucleoside that plays a critical role in cellular energy transfer (as a precursor to ATP) and is used in cosmetics for its well-documented ability to stimulate collagen and elastin synthesis, reduce wrinkle depth, and improve skin firmness. Approved as an anti-wrinkle functional cosmetic ingredient in Korea, adenosine has extensive clinical backing. Used at 0.04% (as per Korean Cosmetics Act) in anti-aging formulations.

cosmetic active ingredients

Aloe Vera Extract (Gel Powder)

CAS: 85507-69-3

Aloe Vera Extract (gel powder) is a concentrated, spray-dried form of Aloe barbadensis leaf gel, standardized for its key bioactive constituents including acemannan polysaccharides, anthraquinones, aloesin, and amino acids, delivering soothing, anti-inflammatory, wound-healing, and moisturizing benefits. It is one of the most universally used cosmetic botanicals with thousands of years of traditional use. Used at 0.5–10% in virtually all cosmetic product categories.

cosmetic active ingredients

Astaxanthin

CAS: 472-61-7

Astaxanthin is a ketocarotenoid pigment produced primarily by the microalgae Haematococcus pluvialis, widely recognized as the most potent natural antioxidant known, with free radical quenching capacity approximately 6000x stronger than vitamin C and 800x stronger than CoQ10. Its unique molecular structure spanning both sides of the cell membrane provides inside-out antioxidant protection, making it exceptionally effective for anti-aging and photoprotection. Used at 0.01–0.1% in premium anti-aging formulations.

cosmetic active ingredients

Azelaic Acid (Cosmetic Grade)

CAS: 123-99-9

Azelaic acid is a naturally occurring dicarboxylic acid with multifunctional benefits including anti-acne, brightening, and anti-inflammatory activity, working by inhibiting tyrosinase and the growth of acne-causing bacteria while normalizing skin cell turnover. It is recommended for oily, acne-prone, and rosacea skin types and is considered safe for use during pregnancy. Typical use concentration is 10–20% in creams and gels.

cosmetic active ingredients

Bakuchiol

CAS: 10309-37-2

Bakuchiol is a meroterpene phenol derived from the seeds of Psoralea corylifolia, functioning as a natural, plant-based retinol alternative that activates retinol-responsive genes without structural similarity to retinoids. Clinical studies show it reduces wrinkles and hyperpigmentation comparably to retinol but with superior tolerability. It is an ideal ingredient for natural, clean-beauty, and sensitive-skin formulations.

cosmetic active ingredients

Beta-Glucan (Oat-Derived, Cosmetic Grade)

CAS: 9041-22-9

Beta-Glucan is a polysaccharide derived from oat bran (Avena sativa) or yeast, recognized as one of the most effective skin-soothing, moisturizing, and immunomodulating actives available, with the unique ability to activate skin Langerhans cells and macrophage receptors to stimulate natural wound healing and skin defense responses. It provides deep hydration, reduces skin redness and sensitivity, and accelerates wound healing. Used at 0.1–1% in soothing, healing, and barrier-strengthening formulations.

cosmetic active ingredients

Carboxymethyl Chitosan HH1

CAS: 83512-85-0

Biotemed HH1 is a water-soluble carboxymethyl chitosan derived from marine-sourced chitin, offering excellent skin absorption, barrier repair and soothing functionality. It forms a breathable biopolymer film that locks in moisture while calming sensitive or stressed skin. Recommended addition level 0.11–2%.

cosmetic active ingredients

Carboxymethyl Chitosan HH2

CAS: 83512-85-0

Biotemed HH2 is a higher-performance grade of carboxymethyl chitosan designed for anti-aging and skin-restructuring applications. Primary functions include skin repair and soothing; secondary benefits include moisturization, firming and anti-wrinkle effects. Recommended addition level 0.11–2%.

cosmetic active ingredients

Centella Asiatica Extract (CICA)

Centella Asiatica Extract, commonly known as CICA, is a standardized extract rich in triterpenoids (asiaticoside, madecassoside, asiatic acid, madecassic acid) that delivers powerful wound healing, skin barrier repair, anti-inflammatory, and collagen-stimulating benefits. It is widely adopted in K-beauty and clinical skincare for sensitive, damaged, and post-procedure skin. Used at 0.1–5% in calming, repairing, and barrier-strengthening formulations.

cosmetic active ingredients

Ceramide AP (Ceramide 6-II)

CAS: 41248-23-1

Ceramide AP (Ceramide 6-II) is an alpha-hydroxy acid substituted ceramide naturally present in the skin's stratum corneum, contributing to the maintenance of the epidermal water barrier and skin structural integrity. It is commonly used in combination with Ceramide NP and EOP to create a balanced multi-ceramide complex mimicking the natural ceramide ratio in healthy skin. Used at 0.01–1% in advanced barrier repair systems.

cosmetic active ingredients

Ceramide EOP (Ceramide 1)

CAS: 113852-37-2

Ceramide EOP (Ceramide 1) is an acylceramide characterized by a linoleic acid esterified to the omega end of a long-chain fatty acid, and is a critical architectural ceramide in the skin barrier that is significantly depleted in atopic dermatitis and dry skin conditions. Its deficiency is directly linked to increased skin permeability and sensitivity. Used at 0.01–0.5% in advanced barrier restoration formulations targeting eczema and compromised skin.

cosmetic active ingredients

Ceramide NP (Ceramide 3)

CAS: 100403-19-8

Ceramide NP (also known as Ceramide 3) is the most abundant ceramide in human stratum corneum, playing a critical role in maintaining the skin's lamellar lipid barrier that prevents transepidermal water loss (TEWL) and protects against environmental aggressors. Topical application replenishes depleted ceramide levels in dry, atopic, and aging skin. Used at 0.01–1% in barrier repair creams, moisturizers, and sensitive skin formulations.

cosmetic active ingredients

Chitosan Glycolate HGC

CAS: 9012-76-4

Biotemed HGC Chitosan Glycolate combines the biopolymer functionality of chitosan with the mild exfoliating and keratin-softening properties of glycolic acid. Provides moisturization, skin firming, and gentle keratin softening. Suitable for anti-aging, exfoliating and skin-smoothing formulations. Recommended addition level 0.11–2%.

cosmetic active ingredients

Chitosan Hydrochloride HYC

CAS: 70694-72-3

Biotemed HYC Chitosan Hydrochloride is a water-soluble cationic chitosan salt with primary film-forming and auxiliary antibacterial functionality. Broad application in skin and hair care for biopolymer film formation. Manufactured to shell-polysaccharide density specification. Recommended addition level 0.11–2%.

cosmetic active ingredients

Chitosan Monosuccinate HDP

CAS: 9012-76-4

Biotemed HDP Chitosan Monosuccinate is an anionic chitosan derivative offering moisturization, film-forming, sensory improvement and foam stabilization. The succinyl modification enhances water solubility and skin compatibility versus native chitosan. Suitable for rinse-off products at 3% (≤2% in leave-on). Recommended addition level 0.11–2%.

cosmetic active ingredients

Chitosan PCA Salt HPC

CAS: 9012-76-4

Biotemed HPC is a chitosan pyrrolidone carboxylate (PCA) salt combining the film-forming and conditioning properties of chitosan with the natural moisturizing factor (NMF) activity of PCA. Provides superior moisturization, film formation and skin conditioning. High usage flexibility at 0.11–7%. Used in leave-on products at ≤7%.

cosmetic active ingredients

Chitosan Salicylate HSS

CAS: 9012-76-4

Biotomed HSS is a chitosan salicylate combining chitosan's biopolymer repair benefits with salicylic acid's anti-inflammatory and keratolytic properties. Primary functions are skin repair and soothing. Water salicylate addition level ≤2% (CIR limit). Maximum use concentration: 50% for rinse-off, 2% for leave-on. Recommended addition level 0.11–2%.

cosmetic active ingredients

Cholesterol (Cosmetic Grade)

CAS: 57-88-5

Cholesterol is an essential sterol lipid that constitutes approximately one-third of the stratum corneum lipids alongside ceramides and fatty acids, forming the multi-lamellar lipid envelope that controls skin permeability. Topical application of cholesterol restores deficient barrier lipid ratios in aged, dry, and compromised skin, significantly reducing transepidermal water loss. Used at 0.1–1% as part of complete barrier lipid systems.

cosmetic active ingredients

Coenzyme Q10 (Ubiquinone, Cosmetic Grade)

CAS: 303-98-0

Coenzyme Q10 (Ubiquinone) is a fat-soluble benzoquinone naturally present in all human cells, where it plays a critical role in mitochondrial energy production and acts as a potent lipophilic antioxidant. Skin levels of CoQ10 decline significantly with age, contributing to reduced cellular energy and increased oxidative damage. Topical supplementation improves skin texture, reduces fine lines, and supports cellular renewal. Used at 0.01–0.3% in anti-aging serums and creams.

cosmetic active ingredients

Copper Peptide GHK-Cu

CAS: 89030-95-5

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper complex peptide found in human plasma, saliva, and urine, with remarkable wound healing, anti-inflammatory, collagen synthesis stimulating, and anti-aging properties. It activates more than 4,000 human genes involved in skin regeneration and repair, including collagen I, III, elastin, and proteoglycan production, while also exhibiting potent antioxidant and anti-inflammatory activity. Used at 0.05–2% in premium regenerating serums and treatments.

cosmetic active ingredients

Cosmetic Chitosan H1

CAS: 9012-76-4

Biotemed H1 is a cosmetic-grade deacetylated chitosan (≥85% deacetylation) offering moisturization, antioxidant and antistatic properties for skin and hair applications. As the base polymer of the Biotemed chitosan line, H1 provides a broad functional platform for biopolymer skin conditioning and hair antistatic formulations. Recommended addition level 0.11–10%.

cosmetic active ingredients

Ectoine

CAS: 96702-03-3

Ectoine is a cyclic amino acid derivative naturally produced by extremophilic bacteria as a stress-protectant molecule, acting as a chemical chaperone that stabilizes proteins, membranes, and DNA against environmental stressors including UV radiation, heat, desiccation, and osmotic stress. In skincare, it provides outstanding moisturization, anti-aging, and anti-inflammatory benefits while protecting skin cells from environmental damage. Used at 0.5–2% in daily protective and anti-aging formulations.

cosmetic active ingredients

Ergothioneine

CAS: 497-30-3

Ergothioneine is a naturally occurring histidine-derived thiol amino acid produced by fungi and actinobacteria, recognized as a 'longevity vitamin' due to its exceptional antioxidant potency surpassing glutathione, vitamins C and E combined, and its ability to accumulate in tissues under oxidative stress. It protects mitochondrial DNA and proteins from oxidative damage and is emerging as a premier anti-aging ingredient. Used at 0.005–0.1% in high-performance anti-aging formulations.