Crospovidone (PVPP)
CAS Number: 9003-39-8
Crospovidone (crosslinked polyvinylpyrrolidone, PVPP) is a highly efficient superdisintegrant that functions primarily through a wicking mechanism rather than swelling. It is insoluble in water and organic solvents, making it chemically stable and compatible with a wide range of APIs. It is effective at low concentrations and produces rapid, consistent tablet disintegration.
Technical Specifications
| appearance | White to creamy white powder |
| pH (1% slurry) | 5.0–8.0 |
| heavy metals (ppm) | ≤10 |
| loss on drying (%) | ≤5.0 |
| nitrogen content (%) | 11.0–12.8 |
Applications
- Tablet and capsule superdisintegrant
- Direct compression formulations
- Orally disintegrating tablets (ODT)
- Moisture-sensitive formulations
- Immediate release dosage forms
Key Features
- Wicking mechanism for rapid disintegration
- Insoluble and chemically stable
- Low use level required
- USP/NF, EP, JP compliant
Send Inquiry
CAS Number
9003-39-8
Category
Pharmaceutical ExcipientsAvailability
In StockSample
Dispatched within 5 days
More in Pharmaceutical Excipients
Ascorbic Acid (Vitamin C, Pharmaceutical Grade)
50-81-7
Benzyl Alcohol (Pharmaceutical Grade Preservative)
100-51-6
Calcium Stearate (Pharmaceutical Grade)
1592-23-0
Carnauba Wax (Pharmaceutical Grade)
8015-86-9
Cellulose Acetate Phthalate (CAP)
9004-38-0
Citric Acid (Pharmaceutical Grade)
77-92-9
Colloidal Silicon Dioxide (Aerosil 200)
7631-86-9
Copovidone VA64 (Kollidon VA64)
25086-89-9