Eudragit E PO (Basic Butylated Methacrylate Copolymer)
CAS Number: 24938-16-7
Eudragit E PO is a cationic copolymer based on dimethylaminoethyl methacrylate that dissolves below pH 5.0 in gastric fluid, making it a gastro-soluble polymer. It is widely used as a taste-masking and moisture-protective film coating for tablets and pellets. It also finds application as a binder and hot melt extrusion carrier for solubilization of poorly soluble drugs.
Technical Specifications
| appearance | White powder with faint amine odor |
| pH of dissolution | ≤5.0 |
| loss on drying (%) | ≤5.0 |
| residual monomer (ppm) | ≤100 |
| dimethylaminoethyl methacrylate content (%) | 20.8–25.5 |
Applications
- Taste masking film coating
- Moisture-barrier coating
- Gastric-soluble immediate release coating
- Hot melt extrusion solubilizer
- Binder in direct compression
Key Features
- Gastro-soluble for rapid gastric release
- Effective taste masking at low coat levels
- Suitable for hot melt extrusion
- Ph.Eur., USP/NF compliant
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CAS Number
24938-16-7
Category
Pharmaceutical ExcipientsAvailability
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