Eudragit RS PO (Ammonio Methacrylate Copolymer Type B)
CAS Number: 33434-24-1
Eudragit RS PO is a water-insoluble copolymer with low permeability, based on neutral methacrylic esters with a small proportion of quaternary ammonium groups. It swells in contact with water and controls drug release through diffusion, providing pH-independent sustained release. It is commonly used in pellet and matrix tablet formulations for extended drug delivery.
Technical Specifications
| appearance | White powder |
| loss on drying (%) | ≤5.0 |
| residual monomer (ppm) | ≤100 |
| quaternary ammonium groups (%) | 4.5–6.8 |
| viscosity 1% in acetone (mPa·s) | ≤15 |
Applications
- Sustained-release pellet coating
- pH-independent controlled release
- Matrix tablet sustained release
- Microparticle coating for SR
- Combination with Eudragit RL for release tuning
Key Features
- pH-independent sustained release
- Water-insoluble, low permeability
- Tunable release by blending with Eudragit RL
- Ph.Eur., USP/NF compliant
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CAS Number
33434-24-1
Category
Pharmaceutical ExcipientsAvailability
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