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Dimethyl Sulfoxide (DMSO)

CAS Number: 67-68-5

Dimethyl sulfoxide (DMSO, ≥99.9%) is an exceptionally versatile polar aprotic solvent with unique skin-penetrating ability, high thermal stability, and complete water miscibility. It is widely used in pharmaceutical formulations as a topical drug carrier, in cryobiology for cell preservation, as a reaction solvent for SNAr and cross-coupling reactions, and in agrochemical formulations.

Technical Specifications

appearanceColorless clear liquid or solid (mp ~18.5°C)
purity (%)≥99.9
water content (%)≤0.03
boiling point (°C)189.0
density (g/mL, 20°C)1.099–1.102

Applications

  • Pharmaceutical topical drug delivery carrier and penetration enhancer
  • Cryoprotective agent for cell, tissue, and stem cell preservation
  • Reaction solvent for SNAr, coupling, and organometallic reactions
  • Agrochemical formulation solvent and penetrant enhancer
  • HPLC mobile phase and analytical reference solvent

Key Features

  • Pharmaceutical-grade ≥99.9% with low peroxide content meeting USP/EP requirements
  • Unique skin-penetrating ability enabling transdermal drug delivery applications
  • Complete miscibility with both water and organic solvents for universal formulation use
  • High thermal stability (bp 189°C) enabling high-temperature synthesis without decomposition

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Dimethyl Sulfoxide (DMSO) chemical structure

CAS Number

67-68-5

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