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Polyethylene Glycol 4000 (PEG 4000, Pharmaceutical Grade)

CAS Number: 25322-68-3

Pharmaceutical grade PEG 4000 is a solid-grade polyethylene glycol with an average molecular weight of 3500–4500 Da, used as a binder, plasticizer, lubricant, and solubilizer in solid and semisolid dosage forms. Its waxy consistency and water solubility make it suitable for melt granulation, tablet coating, and suppository bases. It is non-irritating and biocompatible for multiple administration routes.

Technical Specifications

appearanceWhite waxy solid or flakes
average MW (Da)3500–4500
pH (5% solution)4.5–7.5
loss on drying (%)≤0.5
melting point (°C)53–59
hydroxyl value (mg KOH/g)25–32

Applications

  • Tablet coating binder and plasticizer
  • Melt granulation binder
  • Suppository base
  • Water-soluble tablet lubricant
  • Film coating plasticizer

Key Features

  • Water-soluble lubricant and plasticizer
  • Suitable for melt processing
  • Non-irritating and biocompatible
  • USP/NF, EP compliant

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Polyethylene Glycol 4000 (PEG 4000, Pharmaceutical Grade) chemical structure

CAS Number

25322-68-3

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