Poloxamer 188 (Pluronic F68)
CAS Number: 9003-11-6
Poloxamer 188 (Pluronic F68) is a nonionic block copolymer of polyoxyethylene and polyoxypropylene with an average molecular weight of approximately 8400 Da. It functions as a wetting agent, emulsifier, and solubilizer in oral, parenteral, and topical pharmaceutical formulations. Its unique amphiphilic structure enables micelle formation to improve solubilization of poorly water-soluble APIs.
Technical Specifications
| HLB value | ~29 |
| appearance | White to off-white waxy solid or flakes |
| average MW (Da) | 7680–9510 |
| loss on drying (%) | ≤1.0 |
| pH (2.5% solution) | 6.0–8.0 |
| cloud point (°C, 1% in water) | >100 |
Applications
- Wetting agent for BCS II/IV drugs
- Parenteral emulsion stabilizer
- Solid dispersion solubilizer
- Cell culture media supplement
- Topical cream and gel emulsifier
Key Features
- Nonionic surfactant with high HLB
- Biocompatible for parenteral use
- Excellent emulsification and wetting
- USP/NF, EP compliant
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CAS Number
9003-11-6
Category
Pharmaceutical ExcipientsAvailability
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