Poloxamer 407 (Pluronic F127)
CAS Number: 9003-11-6
Poloxamer 407 (Pluronic F127) is a high-molecular-weight nonionic block copolymer with an average MW of approximately 12,600 Da, exhibiting thermoresponsive gelation properties—flowing as a liquid at low temperatures but forming a gel at body temperature. This unique property makes it ideal for in situ gelling formulations, controlled-release depot systems, and topical vehicles.
Technical Specifications
| HLB value | ~22 |
| appearance | White to off-white waxy solid |
| average MW (Da) | 9840–14600 |
| loss on drying (%) | ≤1.0 |
| pH (2.5% solution) | 6.0–8.0 |
| gelation temperature (10% w/v, °C) | ~14 |
Applications
- Thermoresponsive in situ gelling formulations
- Nasal and ophthalmic drug delivery
- Injectable depot systems
- Topical gel vehicle
- Solubilizer for poorly water-soluble APIs
Key Features
- Thermoresponsive sol-gel transition at ~37°C
- Biocompatible for various administration routes
- High solubilization capacity
- USP/NF, EP compliant
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CAS Number
9003-11-6
Category
Pharmaceutical ExcipientsAvailability
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